O-glycans released by thrombin-activated human platelets

Released O-glycan peak areas from platelet releasates of five human donors following thrombin stimulation.

Usage

glyhub_GPST000211_O(
  kind = c("curated", "raw"),
  cache_dir = getOption("glyhub.cache_dir", tools::R_user_dir("glyhub", "cache")),
  refresh = FALSE,
  offline = FALSE
)

Format

A glyexp::GlycomicSE with 11 features and 5 observations. The abundance assay is in peak area. rowData includes a typed glycan_structure column; features without a supported structure are NA.

Source

GlycoPOST GPST000211. Table S3. Study: https://doi.org/10.1016/j.mcpro.2024.100717. Repository: https://glycopost.glycosmos.org/entry/GPST000211.

Arguments

kind: "curated" returns a data object; "raw" returns the path to a verified source archive. Raw archives are currently available for CPTAC.
cache_dir: Cache directory, defaulting to tools::R_user_dir("glyhub", "cache"). Set option glyhub.cache_dir to change the default.
refresh: Download the pinned resource again, even if cached.
offline: Prohibit downloads; require a verified local resource.

Details

The published total-AUC columns combine the author-measured charge states for each of eleven glycan features. Isomer-resolved features remain distinct. Glycans below 300 Da were outside the reported detection range. Proposed source structures and their known linkages are retained where explicitly represented; the trisialylated feature has unresolved sialic-acid attachment topology and retains composition-level annotation.

Source composition counts and proposed structures cross-checked against the source table images and deposited GlycoWorkbench workspace; unresolved topology remains missing.

Access

Use glyhub_load("glyhub_GPST000211_O") to load this dataset.