Swift Universal Glycan Acquisition (SUGA) Enables Quantitative Glycan Profiling across Diverse Sample Types. and related study experiments

Native unreduced released N-glycan composition quantification. Drug treatment/time is column metadata; includes three identified blanks. Combined N-glycan quantitative profiles from GPST000431. 70 union features and 62 source observations are represented.

Usage

glyhub_GPST000431_N(
  kind = c("curated", "raw"),
  cache_dir = getOption("glyhub.cache_dir", tools::R_user_dir("glyhub", "cache")),
  refresh = FALSE,
  offline = FALSE
)

Format

A glyexp::GlycomicSE with 70 features and 62 observations. The abundance assay is in MS1 integrated area. rowData has no glycan_structure column because no feature has a supported structural annotation.

Source

GlycoPOST GPST000431. SUGA_DrugTreatments_GlycanQuant. Study: https://doi.org/10.1021/acs.jproteome.4c00657. Repository: https://glycopost.glycosmos.org/entry/GPST000431. Quantitative source: https://glycopost.glycosmos.org/data/GPST000431.1/SUGA_DrugTreatments_GlycanQuant_treatmentkey.xlsx.

Arguments

kind: "curated" returns a data object; "raw" returns the path to a verified source archive. Raw archives are currently available for CPTAC.
cache_dir: Cache directory, defaulting to tools::R_user_dir("glyhub", "cache"). Set option glyhub.cache_dir to change the default.
refresh: Download the pinned resource again, even if cached.
offline: Prohibit downloads; require a verified local resource.

Details

Source experiments are identified in colData and original panel-specific metadata, annotations and measurements are retained in metadata. Feature identities are aligned only when supported by author identifiers or explicit molecular structures; other features retain source-specific identities. The source_coverage matrix distinguishes unmeasured combinations from measured missing values. Units: MS1 integrated area.

Swift Universal Glycan Acquisition (SUGA) Enables Quantitative Glycan Profiling across Diverse Sample Types.: Native unreduced released N-glycan composition quantification. Drug treatment/time is column metadata; includes three identified blanks.

Swift Universal Glycan Acquisition (SUGA) Enables Quantitative Glycan Profiling across Diverse Sample Types.: Native unreduced released N-glycan composition quantification. Independent method benchmark; distinct experiments are retained in column metadata.

Molecular annotations retain source precision. Unresolved compositions or structures are NA; original annotations are retained in rowData. All quantitative source features are preserved.

Access

Use glyhub_load("glyhub_GPST000431_N") to load this dataset.