Human intervertebral-disc N-glycan chromatographic profiles

Thirty-two shared HILIC-UPLC N-glycan peaks quantified in six biological replicates each of healthy and degenerated annulus fibrosus and nucleus pulposus tissue.

Usage

glyhub_GPST000625_N(
  kind = c("curated", "raw"),
  cache_dir = getOption("glyhub.cache_dir", tools::R_user_dir("glyhub", "cache")),
  refresh = FALSE,
  offline = FALSE
)

Format

A glyexp::GlycomicSE with 32 features and 24 observations. The abundance assay is in relative peak area (%). rowData has no glycan_structure column because no feature has a supported structural annotation.

Source

GlycoPOST GPST000625. UPLC_covariance_bio replicates. Study: https://doi.org/10.1002/advs.202506669. Repository: https://glycopost.glycosmos.org/entry/GPST000625.

Arguments

kind: "curated" returns a data object; "raw" returns the path to a verified source archive. Raw archives are currently available for CPTAC.
cache_dir: Cache directory, defaulting to tools::R_user_dir("glyhub", "cache"). Set option glyhub.cache_dir to change the default.
refresh: Download the pinned resource again, even if cached.
offline: Prohibit downloads; require a verified local resource.

Details

Dataset S2 contains the full individual-replicate percentage-area matrix. Glycan peaks may contain coeluting species, so peak identities are retained without assigning a single composition or structure. The separate 48-peak pooled-sample structural-deconvolution analysis is retained in the source workbook and is not equated to the 32-peak individual-replicate feature space. No glycan identities are inferred from peak numbers.

UPLC peak-level quantitative features; 32 individual-sample peaks cannot be uniquely matched to 48 pooled structural fractions. Composition and structure are intentionally missing; source peak identities are retained.

Access

Use glyhub_load("glyhub_GPST000625_N") to load this dataset.