Whole-brain N-glycans in Slc35a3-deficient mice

N-glycan amounts in whole-brain tissue from wild-type, heterozygous and Slc 35 a 3-knockout mice, with three source observations per genotype.

Usage

glyhub_GPST000647_N(
  kind = c("curated", "raw"),
  cache_dir = getOption("glyhub.cache_dir", tools::R_user_dir("glyhub", "cache")),
  refresh = FALSE,
  offline = FALSE
)

Format

A glyexp::GlycomicSE with 179 features and 9 observations. The abundance assay is in pmol per 100 micrograms protein. rowData has no glycan_structure column because no feature has a supported structural annotation.

Source

GlycoPOST GPST000647. Supplementary Table 1. Study: https://doi.org/10.3390/ijms27041643. Repository: https://glycopost.glycosmos.org/entry/GPST000647.

Arguments

kind: "curated" returns a data object; "raw" returns the path to a verified source archive. Raw archives are currently available for CPTAC.
cache_dir: Cache directory, defaulting to tools::R_user_dir("glyhub", "cache"). Set option glyhub.cache_dir to change the default.
refresh: Download the pinned resource again, even if cached.
offline: Prohibit downloads; require a verified local resource.

Details

The 179 rows include paucimannose, high-mannose, hybrid, neutral-complex and acidic-complex features. Paucimannose counts are literal; other source counts describe residues beyond the Hex 3 HexNAc 2 N-glycan core. Full compositions include this core, consistent with the reported mass series and the paper core-plus-HexNAc convention. Source alpha 2,3/alpha 2,6 sialic-acid counts are retained as partial linkage annotations; predicted SNFG cartoons are not promoted to experimentally resolved isomer structures.

Source-derived composition annotations; linkage information is retained as source annotation without inferring a full topology. No complete unambiguous structures are asserted.

Access

Use glyhub_load("glyhub_GPST000647_N") to load this dataset.