Whole-brain O-glycans in Slc35a3-deficient mice

O-glycan amounts in whole-brain tissue from wild-type, heterozygous and Slc 35 a 3-knockout mice, with three source observations per genotype.

Usage

glyhub_GPST000650_O(
  kind = c("curated", "raw"),
  cache_dir = getOption("glyhub.cache_dir", tools::R_user_dir("glyhub", "cache")),
  refresh = FALSE,
  offline = FALSE
)

Format

A glyexp::GlycomicSE with 25 features and 9 observations. The abundance assay is in pmol per 100 micrograms protein. rowData has no glycan_structure column because no feature has a supported structural annotation.

Source

GlycoPOST GPST000650. Supplementary Table 2. Study: https://doi.org/10.3390/ijms27041643. Repository: https://glycopost.glycosmos.org/entry/GPST000650.

Arguments

kind: "curated" returns a data object; "raw" returns the path to a verified source archive. Raw archives are currently available for CPTAC.
cache_dir: Cache directory, defaulting to tools::R_user_dir("glyhub", "cache"). Set option glyhub.cache_dir to change the default.
refresh: Download the pinned resource again, even if cached.
offline: Prohibit downloads; require a verified local resource.

Details

The source study profiles nucleotide-sugar transporter deficiency using MALDI-TOF MS. Twenty-five annotated features are retained, including source-undetected rows. Sialic-acid linkage labels remain in row annotations; the paper describes composition-based assignments and does not resolve all isomeric structures. Quantitative zeros are represented as missing values, with original measurements and masks retained.

Source-derived composition annotations; linkage information is retained as source annotation without inferring a full topology. No complete unambiguous structures are asserted.

Access

Use glyhub_load("glyhub_GPST000650_O") to load this dataset.